Bioactives demonstrate strong biological potential across health. Most of them fail to deliver measurable outcomes.
Low Bioavailability
Bioactives degrade before reaching the action site.
Low Bioavailability
Bioactives degrade before reaching the action site.
Wrong Absorption-Site
Compounds are absorbed
too early.
Wrong Absorption-Site
Compounds are absorbed
too early.
Limited Efficacy
Dose escalation cannot fix delivery failure.
Limited Efficacy
Dose escalation cannot fix delivery failure.
Biology Works.
Biology Works.
Biology Works.
Products Fail Because Delivery Does.
Products Fail Because Delivery Does.
Products Fail Because Delivery Does.
It plays a critical role in epithelial integrity, inflammation regulation, and metabolic balance. Yet, current delivery systems rarely allow it to get into colon cells intact.
The science is established.
The delivery system is not.
The science is established.
The delivery system is not.
Butyrate-loaded Clepsules™ demonstrated more than double functional impact compared to standard oral delivery.
Clepsule™ Delivery
Greater Efficacy
Standard Oral Delivery
Reduced functional delivery
Clepsule™ Delivery
Greater Efficacy
Standard Oral Delivery
Reduced functional delivery
Clepsule™ is a bacterial extracellular vesicles based delivery platform engineered for targeted cell interaction
Delivers bioactives intact to the gut.
Delivers bioactives intact to the gut.
Shields bioactives from
early degradation.
Shields bioactives from
early degradation.
Shields bioactives from early degradation.
Loads a wide-range of bioactive compounds.
Loads a wide-range of bioactive compounds.
Recognized and internalized
by target cells.
Recognized and internalized
by target cells.
Recognized and internalized by target cells.
Delivery Defines
Performance.
Delivery Defines
Performance.
Delivery Defines
Performance.
Explore the Compounds
Scroll and choose a compound to learn about its biological functions and potential benefits.
Short-chain fatty acid involved in gut health.
Epithelial barrier integrity
Inflammation regulation
Gut-brain signaling
Biological molecules involved in gene regulation.
Gene expression control
Cellular signaling
Precision biological effects
One of the body’s main cellular antioxidants.
Oxidative stress protection
Detoxification support
Immune balance
Small signaling molecules involved in cellular communication.
Metabolic regulation
Cellular signaling
Hormonal balance
Biological catalysts of metabolic reactions.
Digestive support
Metabolic processes
Cellular activity
Key phospholipid involved in brain cell membranes.
Cognitive performance
Stress response
Memory support
Primary inhibitory neurotransmitter in the nervous system.
Relaxation
Sleep regulation
Mood balance
Explore the Compounds
Scroll and choose a compound to learn about its biological functions and potential benefits.
Peptides
Enzymes
Phosphatidylserine
GABBA
Butyrate
RNA's
Glutathione
Peptides
Enzymes
Phosphatidylserine
GABBA
Butyrate
RNA's
Glutathione
Peptides
Enzymes
Phosphatidylserine
GABBA
Short-chain fatty acid involved in gut health.
Epithelial barrier integrity
Inflammation regulation
Gut-brain signaling
Biological molecules involved in gene regulation.
Gene expression control
Cellular signaling
Precision biological effects
One of the body’s main cellular antioxidants.
Oxidative stress protection
Detoxification support
Immune balance
Small signaling molecules involved in cellular communication.
Metabolic regulation
Cellular signaling
Hormonal balance
Biological catalysts of metabolic reactions.
Digestive support
Metabolic processes
Cellular activity
Key phospholipid involved in brain cell membranes.
Cognitive performance
Stress response
Memory support
Primary inhibitory neurotransmitter in the nervous system.
Relaxation
Sleep regulation
Mood balance
Explore the Compounds
Scroll and choose a compound to learn about its biological functions and potential benefits.
Peptides
Enzymes
Phosphatidylserine
GABBA
Butyrate
RNA's
Glutathione
Peptides
Enzymes
Phosphatidylserine
GABBA
Butyrate
RNA's
Glutathione
Peptides
Enzymes
Phosphatidylserine
GABBA
Short-chain fatty acid involved in gut health.
Epithelial barrier integrity
Inflammation regulation
Gut-brain signaling
Biological molecules involved in gene regulation.
Gene expression control
Cellular signaling
Precision biological effects
One of the body’s main cellular antioxidants.
Oxidative stress protection
Detoxification support
Immune balance
Small signaling molecules involved in cellular communication.
Metabolic regulation
Cellular signaling
Hormonal balance
Biological catalysts of metabolic reactions.
Digestive support
Metabolic processes
Cellular activity
Key phospholipid involved in brain cell membranes.
Cognitive performance
Stress response
Memory support
Primary inhibitory neurotransmitter in the nervous system.
Relaxation
Sleep regulation
Mood balance
What is BioClé?
We are a biotechnology company developing a delivery platform based on bacterial extracellular vesicles (bEVs) to transform bioactive compounds into more effective products by enhancing their stability, bioavailability, and cellular uptake.
What are bEVs?
Bacterial extracellular vesicles ("bEVs") are nanoscale vesicles naturally produced by bacteria, optimized by nature to transport molecules and communicate with host cells; they can carry and protect bioactive compounds while interacting with intestinal cells.
Is the vesicle just a carrier?
No. Vesicles can also carry intrinsic biological components, such as metabolites like short-chain fatty acids, contributing to the overall functional effect.
What is your first product?
Our first application focuses on Butyrate, a key microbiome derived metabolite associated with gut and metabolic health; current formulations face limitations in stability, delivery, and user experience.
What else are you developing?
We are building a pipeline organized around categories of bioactives where delivery is the main limitation. For each category, we select a lead compound to validate performance and unlock broader applications.
How will your product portfolio evolve?
We are building a portfolio of high performance product categories enabled by delivery, expanding from lead compounds into multiple use cases and markets.
We are developing a compound with strong potential but poor bioavailability. Can BioClé help?
Yes. BioClé is designed to address exactly this kind of challenge. We start with a feasibility assessment to evaluate compatibility and define the optimal delivery strategy, followed by validation and potential co-development. If you are interested in evaluating your bioactive compound within ClépsulesTM platform, you can contact our team to discuss feasibility.
We are a biotechnology company developing a delivery platform based on bacterial extracellular vesicles (bEVs) to transform bioactive compounds into more effective products by enhancing their stability, bioavailability, and cellular uptake.
Bacterial extracellular vesicles ("bEVs") are nanoscale vesicles naturally produced by bacteria, optimized by nature to transport molecules and communicate with host cells; they can carry and protect bioactive compounds while interacting with intestinal cells.
No. Vesicles can also carry intrinsic biological components, such as metabolites like short-chain fatty acids, contributing to the overall functional effect.
Our first application focuses on Butyrate, a key microbiome derived metabolite associated with gut and metabolic health; current formulations face limitations in stability, delivery, and user experience.
We are building a pipeline organized around categories of bioactives where delivery is the main limitation. For each category, we select a lead compound to validate performance and unlock broader applications.
We are building a portfolio of high performance product categories enabled by delivery, expanding from lead compounds into multiple use cases and markets.
Yes. BioClé is designed to address exactly this kind of challenge. We start with a feasibility assessment to evaluate compatibility and define the optimal delivery strategy, followed by validation and potential co-development. If you are interested in evaluating your bioactive compound within ClépsulesTM platform, you can contact our team to discuss feasibility.
Biology Works.
Biology Works.
Biology Works.
Products Fail Because Delivery Does.
Products Fail Because Delivery Does.
Products Fail Because Delivery Does.
